何裕隆，男，主任医师，教授，胃肠胰外科主任，博士导师。医疗专长： 1.擅长于胃肠道良、恶性肿瘤的诊断与治疗，率先在国内开展超扩大治好术（D4）、Appleby手术和Whipple手术治疗进展期胃癌，以及联合器官簇移植治疗晚期胃肠肿瘤。在胃癌治好术、全直肠系膜切除、低位保留肛部和保护性功能的直肠癌治好术、结肠“J” 型贮袋重建直肠术等方面有深入的研究和丰富的经验；2.对于胰腺疾病、腹膜后肿瘤、食道癌、食道良性疾病、结直肠息肉及息肉病等有丰富的诊治经验，尤其在食道癌治好术、胃或结肠代食道术、保留幽门的Whipple术、全结肠切除术、消化道重建术等方面在国内属于率先水平；3.对胃肠道间质瘤有丰富的诊治经验，率先开展了国内多中性研究，建立了胃肠道间质瘤资料库；4、普通外科常见病和多发病的诊治有丰富的临床经验，对普通外科疑难病症的诊治有独到的见解；4.熟练应用腹腔镜及消化道内镜对胃肠道疾病进行诊断和治疗， 采用快速康复外科和微创外科的理念，指导临床促进病人康复。 主要研究方向： 1. 胃肠肿瘤的诊治和基础研究2.肿瘤淋巴结转移机制和防治的研究3.胃肠道间质瘤基础临床研究4.遗传性胃肠道疾病的研究5.结直肠癌的早期诊断和外科治疗6.胰腺疾病的诊治与基础研究科研基金 获、省部级自然科学基金多项；参与211工程、985工程及自然科学基金等多项科研项目。在核心期刊发表论文200余篇，其中SCI论文20余篇。“提高胃癌外科的临床与基础研究”分别获得2005年度中华医学会医学科技进步二等奖和2005年度广东省科技进步二等奖；“直肠癌保功能手术”获得2006年度广东省科技进步一等奖；“进展期胃癌外科治疗及应用基础研究”获2009年广东省科技进步奖二等奖。 社会兼职 现任亚洲外科学会会员，中华医学会外科学分会委员，中华医学会外科学分会胃肠外科学组副组长，抗癌协会胃癌专业委员会副主任委员，医师协会第二届医学教育委员会委员，临床肿瘤学会（CSCO）胃肠间质瘤专员会副组长，广东省医学会胃肠外科学分会主任委员，广东省抗癌协会第三届理事会常务理事，广东省医学会第七届理事会理事，广东省抗癌协会胃癌专业委员会副主委，广东省抗癌协会胰腺癌专业委员会副主任，广东省抗癌协会大肠癌专业委员会常委，广东省医学会外科学分会第八届委员会常委，和广东省自然科学基金评委，中华医学科技奖评委，广东省科技奖评委，《消化肿瘤杂志》(电子版)主编、《中华胃肠外科杂志》副主编、《中华普通外科文献》编辑部副主任、Annals of Surgery、Journal of Surgical Oncology、《中华外科杂志》、《实用外科杂志》、《中华普通外科杂志》等10余种杂志编委。情况 1.《胰岛移植》荣获1992年度三等奖和广东省卫生厅二等奖2.《提高胃癌的基础与临床研究》荣获2005年度中华医学会科技进步二等奖和广东省科技进步二等奖3.《直肠癌保功能手术提高患者生存质量的序列研究》荣获2007年度广东省科技进步一等奖4“进展期胃癌外科治疗及应用基础研究”获2009年广东省科技进步奖二等奖。论 著 在核心期刊发表论文200余篇，其中SCI论文20余篇。1. High expression of PRL-3 can promote growth of gastric cancer and exhibits a poor prognostic impact on patients. Wang Z, Cai SR, He YL, Zhan WH, Chen CQ, Cui J, Wu WH, Wu H, Song W, Zhang CH, Peng JJ, Huang XH. Ann Surg Oncol. 2009 Jan; 16(1):208-19.2. Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients. Wang Z, Cai SR, He YL, Zhan WH, Zhang CH, Wu H, Peng JJ, Xu JB, Zhang XH, Wang L, Song W. J Cancer Res Clin Oncol. 2009 Aug;135(8):1041-10463. Clinicopathologic features and survival of patients with colorectal mucinous,sigent-ring cell or non-mucinous adenocarcinoma:experience at an institution in southern China. Song wu.wu sui-,He yu-long,cai shi-rong,zhang chang-hua,zhang xin-hua and zhan wen-hua. Chinese Medical Journal. 2009,7,122(13):1486-14914．Early operation for fulminant acute pancreatitis:a possible way to decrease mortality. Yang dong-jie he yu-long,cai shi-rong,peng jian-jun,zhang chang-hua and zhan wen-hua. Chinese Medical Journal. 2009,7,122(13):1492-14945．Comparison of patients by family history with gastric and non-gastric cancer. Xue-Fu Zhou,Yu-Long He,Wu Song,Jian-Jun Peng,Chang-Hua Zhang,Wen Li,Hui Wu. World J Gastroenterol. 2009,7,15(21):2644-26506．Detection of hMSH2 and hMLH1 mutations in Chinese hereditary non-polyposis colorectal cancer kindreds. Zhang CH, He YL, Wang FJ, Song W, Yuan XY, Yang DJ, Chen CQ, Cai SR, Zhan WH. World J Gastroenterol. 2008 Jan 14;14(2):298-3027． Expression and prognostic impact of PRL-3 in lymph node metastasis of gastric cancer: its molecular mechanism was investigated using artificial microRNA interference. Wang Z, He YL, Cai SR, Zhan WH, Li ZR, Zhu BH, Chen CQ, Ma JP, Chen ZX, Li W, Zhang LJ. Int J Cancer. 2008 Sep 15; 123(6):1439-478． Is albumin administration beneficial in early stage of postoperative hypoalbuminemia following gastrointestinal surgery?: a prospective randomized controlled trial. Yuan XY, Zhang CH, He YL, Yuan YX, Cai SR, Luo NX, Zhan WH, Cui J. Am J Surg. 2008 Nov;196(5):751-59． Role of silencing phosphatase of regenerationg liver-3 expression by microRNA interference in the growth of gastric cancer. Cai SR, Wang Z, Chen CQ, Wu WH, He YL, Zhan WH, Zhang CH, Cui J, Wu H. Chin Med J (Engl). 2008 Dec 20;121(24):2534-810． Spleen preservation in radical surgery for gastric cardia cancer. Zhang CH, Zhan WH, He YL, Chen CQ, Huang MJ, Cai SR. Ann Surg Oncol. 2007 Apr; 14(4):1312-9.11． Vagina vasorum dissection during D2 lymphadenectomy for gastric carcinoma. Peng JJ, He YL, Zhan WH, Xiao P, Cai SR, Zhang CH, Wu H. World J Gastroenterol. 2007 Mar 28;13(12):1867-912． Clinical ysis of eight kindreds of familial adenomatous polyposis. He YL, Zhang CH, Huang MJ, Cai SR, Zhan WH, Wang JP, Wang JF. World J Gastroenterol. 2004 Dec 15;10(24):3659-61.13． Comparison of patients by family history with gastric and non-gastric cancer. Zhou XF, He YL, Song W, Peng JJ, Zhang CH, Li W, Wu H. World J Gastroenterol. 2009 Jun 7;15(21):2644-50.14． Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. SONG Wu, WU Sui-, HE Yu-long, C Shi-rong, ZHANG Changhua, ZHANG Xin-hua, et al. Chin Med J (Engl). 2009 Jul 5; 122(13):1486-1491.15． Early operation for fulminant acute pancreatitis: a possible way to decrease mortality. YANG Dong-jie, HE Yu-long, C Shi-rong, PENG Jian-jun, ZHANG Chang-hua and ZHAN Wen-hua. Chin Med J (Engl). 2009 Jul 5; 122(13): 1492-1494.16． Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers on lymphangiogenesis of gastric cancer in a nude mouse model. Wang L, Cai SR, Zhang CH, He YL, Zhan WH, Wu H, Peng JJ. Chin Med J (Engl). 2008 Nov 5;121(21):2167-7117． (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis. Zhu BH, Zhan WH, Li ZR, Wang Z, He YL, Peng JS, Cai SR, Ma JP, Zhang CH. World J Gastroenterol. 2007 Feb 28;13(8):1162-918． Association of tyrosine PRL-3 phosphatase protein expression with peritoneal metastasis of gastric carcinoma and prognosis. Li ZR, Wang Z, Zhu BH, He YL, Peng JS, Cai SR, Ma JP, Zhan WH. Surg Today. 2007;37(8):646-5119． Effect of lymph node micrometastases on prognosis of gastric carcinoma. Wu ZY, Li JH, Zhan WH, He YL, Wan J. World J Gastroenterol. 2007 Aug 14;13(30):4122-520． Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma. Wu ZY, Li JH, Zhan WH, He YL. World J Gastroenterol. 2006 May 14;12(18):2941-421． Right hemicolectomy combined with pancreatico- duodenectomy for the treatment of colon carcinoma invading the duodenum or pancreas. Song XM, Wang L, Zhan WH, Wang JP, He YL, Lian L, Cai GF, Zhou HF, Huang BY, Lan P. Chin Med J (Engl). 2006 Oct 20; 119(20): 1740-322． Expression of E-cadherin in gastric carcinoma and its correlation with lymph node micrometastasis. Wu ZY, Zhan WH, Li JH, He YL, Wang JP, Lan P, Peng JS, Cai SR. World J Gastroenterol. 2005 May 28; 11(20):3139-4323． Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas. Chen JQ, Zhan WH, He YL, Peng JS, Wang JP, Cai SR, Ma JP. World J Gastroenterol. 2004 Mar 15; 10(6): 776-8224． The effect of FasL gene transfer to islet cells on pancreatic islet allografts. Cai SR, He YL, Huang MJ, Peng JS, Wang JP, Zhan WH. Hepatobiliary Pancreat Dis Int. 2003 May; 2(2): 308-1225． The effect of FasL expression on pancreatic islet allograft Zhan Wenhua,Cai Shirong,Wang Jianping,He Yulong,Zheng Zhangqing,Peng Junsheng. Chin Med J (Engl). 2002 Jul; 115(7): 1006-926． Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma. Ma Jinping,Zhan Wenhua,Peng Junsheng,He Yulong,Zheng Zhangqing,Cai Shirong,Wang Lei,Wang Jianping. Chin Med J (Engl). 2001 Oct; 114(10): 1068-72专 著 主编和参编《消化肿瘤外科学》、《胃肠外科手术学》、《外科学》本科教材、《外科临床手册》、《直肠癌保肛手术》等著作。培养博士后、博士研究生、硕士研究生多名。
