吴钟凯，男，主任医师，教授，研究员，心血管医学部副主任，心脏外科副主任，博士导师，博士学历，毕业于2001年。一直在临床一线工作的心脏外科医生，临床经验丰富。每年主刀手术150-230例，临床医果达到国内先进水平。医德医风优良，从医25年来，无投诉和医疗问题。医疗专长 熟悉先天性心脏病、心脏瓣膜病和冠心病外科手术治疗及术前后诊治处理。擅长冠脉搭桥术包括不停跳冠脉搭桥术手术。在冠心病高发区芬兰从事心脏外科临床工作和临床研究4年，有近千例冠脉搭桥手术主刀及一助经验。对心脏术中心肌保护有较深的造诣和一定的国际影响。保留瓣下结构二尖瓣置换术对提高重症二尖瓣病变的治果，瓣膜整形和心房纤颤的外科治疗有深入的研究。在大学、医院带领支持下和社会慈善机构的帮助下，创立‘爱济童心’慈善基金，资助贫困地区和贫困家庭的先心病患者手术。是杰出青年科学基金获得者、“新世纪百千万人才工程”人才、第十一届广州十大杰出青年、享受国务院特殊津贴医生、广东省高等学校珠江学者特聘教授。 主要研究方向心脏手术术中心肌保护；不停跳冠脉搭桥手术；心肺移植。 社会兼职 辅助循环核心实验室副主任，心血管医学部副主任。第十二届、第十三届自然基金委医生评审医生成员（二审医生）。《中华胸心血管外科杂志》第六届编辑委员会编辑委员专业杂志Chinese Journal of Clinical Medicine （Engl）编委。专业杂志中华临床医师杂志（电子版）Chinese Journal of Clinicians常务编委。新医学编委。岭南心血管杂志编委。membership in the Scandinavian Society for Research in Cardiothoracic Surgery专业杂志《Circulation》、《The Annals of Thoracic Surgery》、《The American Journal of Cardiology》、《Chest》和《Chinese Medical Journal》审稿人。医师协会心血管外科医师分会学术委员会委员广东省医师协会心血管外科医师分会常务委员。广东省心胸外科协会委员。广州市青年联合会常务委员。情况 2002年芬兰心胸外科特别奖，2003年北欧心胸外科协会年度奖Karl Victor Hall Award。2005年杰出青年科学基金获得者。2006年“新世纪百千万人才工程”人才。2006年广东省千百十工程省级培养对象。2010年第十一届广州十大杰出青年2010年获国务院特殊津贴医生2010年广东省千百十工程先进个人2011年广东省珠江学者特聘教授2011年北欧心胸外科协会年度奖Karl Victor Hall Award。 论著 共发表论文74篇，其中SCI 杂志发表作者和通讯作者论文26 篇。在SCI 杂志发表的作者和通讯作者论文：1. Simvastatin attenuates pulmonary vascular remodeling by down-regulating matrix metalloproteinases-1,9 expressions in carotid artery-jugular vein shunt pulmonary hypertension model of rats. Eur. J. Cardiothorac. Surg 2012; (付印，通讯作者).2. Controlled Oxygen Reperfusion Protects the Lung against Early Ischemia- Reperfusion Injury in Cardiopulmonary Bypasses by Down-regulating High Mobility Group Box 1 Experimental Lung Research 2012（付印，通讯作者).3. Mai Xiong, Zhong-Kai Wu. Fibrosis of pulmonary vascular remodeling in carotid artery-jugular vein shunt pulmonary artery hypertension model of rats. Eur. J. Cardiothorac. Surg 2012; 41(1): p. 162-166 (通讯作者).4. Gao X, Peng L, Zeng Q, Wu ZK. Relationship between autonomic nervous function and arrhythmias in patients with acute viral myocarditis. Cardiology. ,2009,113(1):66-71. (通讯作者).5. Wu ZK, Laurikka J, Vikman S, Nieminen R, Moilanen E, Tarkka MR. High Postoperative Interleukin-8 Levels Related to Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Surgery.World J Surg. 2008 Dec;32(12):2643-9. (通讯作者).6. Xu YQ, Wu ZK. Successfully surgical correction of total anomalous systemic venous drainage: two cases report. Heart Surgery Forum 2007;10(5):E415-7 (通讯作者).7. ZK Wu, S Vikman, J Laurikka, E Pehkonen, T Iivainen, HV Huikuri, and MR Tarkka. Nonlinear heart rate variability in CABG patients and the preconditioning effect. Eur. J. Cardiothorac. Surg 2005; 28: 109-13. (通讯作者).8. Zhang X, Wu ZK, Yao JP, et al. Aortopulmonary window—a case diagnosed by UFCT and the corrected method after transaortic patch closure with aortic narrowing. Chinese Medical Journal 2004;117：1750-1752。(通讯作者)9. Wu ZK, Iivainen T, Pehkonen E, et al. The antiarrhythmic effect of ischemic preconditioning in recent unstable angina patients undergoing coronary artery bypass grafting. World J Surg. 2004;28:74-9. 10. Wu ZK, Iivainen T, Pehkonen E, et al. Recent unstable angina and off-pump coronary artery bypass grafting is not related to postoperative atrial fibrillation。Scand Cardiovasc J. 2003;37:334-9.11. Wu ZK, Iivainen T, Pehkonen E, et al. Fibrillation in patients subjected to coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2003;126:1477-82.12. Wu ZK, Iivainen T, Pehkonen E, et al. Arrhythmias in off-pump coronary artery bypass grafting patients and the antiarrhythmic effect of regional ischemic preconditioning. J Cardiothorac Vasc Anesth 2003;17:459-64. 13. Wu ZK, Laurikka J, Saraste A, et al. Cardiomyocyte apoptosis and ischemic preconditioning in open heart operations. Ann Thorac Surg 2003;76:528-534.14. Wu ZK, Iivainen T, Pehkonen E, et al. Perioperaive and postoperative arrhythmia in 3-vessel coronary artery disease patients and antiarrhythmic effects of ischemic preconditioning. European J of Cardio-thoracic Surg 2003;23: 578-584.15. Tarkka MR, Wu ZK. Ischemic preconditioning in cardiac surgery. Int J Angiology 2003;12:34-47. (通讯作者)16. Wu ZK, Iivainen T, Pehkonen E, et al. Ischemic preconditioning suppresses ventricular tachyarrhythmias after myocardial revascularization Circulation. 2002;106:3091-3096.17. Wu ZK, Pehkonen E, Laurikka J, et al. Ischemic preconditioning protects right ventricular function in coronary artery bypass grafting patients experiencing angina within 48-72 hours. J Cardiovasc Surg 2002;43:319-26.18. Wu ZK, Pehkonen E, Laurikka J, et al. The protective effects of preconditioning decline in aged patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2001;122:972-8. 19. Wu ZK, Pehkonen E, Laurikka J, et al. Preceding unstable angina affects inflammatory response and haemodynamics after coronary artery bypass surgery. International J of Angiology 2001;10:80-84. 20. Wu ZK, Pehkonen E, Laurikka J, et al. Myocardial lactate production is not involved in the ischaemic preconditioning mechanism in CABG patients. J Cardiothorac Vasc Anesth. 2001;15:412-7. 21. Wu ZK, Tarkka MR, Eloranta J, et al. Effect of ischaemic preconditioning, cardiopulmonary bypass and myocardial ischaemic/reperfusion on free radicals generation in CABG patients. Cardiovasc Surg. 2001;9:362-8. 22. Wu ZK, Tarkka MR, Eloranta J, et al. Effect of ischemic preconditioning (IP) on myocardial protection in CABG patients: Can the free radicals act as a trigger for IP? Chest 2000; 119:1061-8. 23. Wu ZK, Pehkonen E, Laurikka J, et al. Protective effect of unstable angina in coronary artery bypass surgery. Scand Cardiovasc J 2000;34: 486-492.24. Wu ZK, Tarkka MR, Pehkonen E, et al. Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting. Ann Thorac Surg. 2000;70:1551-7.25. Wu ZK, Sun PW, Zhang X, et al. Superiority of Mitral Valve Replacement with Preservation of Subvalvular Structure to Conventional Replacement in Severe Rheumatic Mitral Valve Disease. J Heart Valve Dis 2000;9:616-622.26. Wu ZK, Tarkka MR, Pehkonen E, et al. Ischaemic Preconditioning has a Beneficial Effect on Left Ventricular HeamodynamicSCI 杂志发表的第二作者等论文：27. Liu Z, Vuohelainen V, Tarkka M, Tenhunen J, Lappalainen RS, Narkilahti S, Paavonen T, Oksala N, Wu Z, Mennander A. Glutamate release predicts ongoing myocardial ischemia of rat hearts Scand J Clin Lab Invest. 2010;70:217-24.28. Huang SH, Gu LJ, Rong JIAN, Wu ZK. Dynamics of interstitial calcium in rat myocardial ischemia reperfusion injury in vivo. EUROPEAN HEART JOURNAL SUPPLEMENTS 2010，12：F18. (摘要，通讯作者)29. Zhang X, Xiong M, Wang ZP, Yin SL, Wu ZK, Xu YQ, Tang BY, Yao JP, Chen GX. Heart-lung transplantation for end-stage heart disease with Eisenmenger's syndrome: report of two cases. Chin Med J (Engl). 2009;122:2189-92. 30. Huang G, Wang A, Li X, Long M, Du Z, Hu C, Luo C, Wu Z, Tang L.Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation. J Hypertens. 2009;27:1829-1837.31. Huang G, Luo C, Gu X, Wu Z, Wang Z, Du Z, Hu C, Tang L.Mechanical strain induces expression of C-reactive protein in human blood vessels. J Pharmacol Exp Ther. 2009;330:206-11.32. He J, Chen Y, Huang Y, Yao F, Wu ZK, Chen S, Wang L, Xiao P, Dai G, Meng R, Zhang C, Tang L, Huang Y, Li Z. Effect of long-term B-type natriuretic peptide treatment on left ventricular remodeling and function after myocardial infarction in rats. Eur J Pharmacol. 2009;602:132-7.33. Czibik G, Wu Z, Berne GP, Tarkka M, Vaage J, Laurikka J, J?rvinen O, Valen G.Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart. Eur J Cardiothorac Surg. 2008;34:976-84.31. Liu WB, Xia Q, Men LN, Wu ZK, Huang RX. Dysphonia as a primary manifestation in myasthenia gravis (MG): a retrospective review of 7 cases among 1520 MG patients. J Neurol Sci. 2007;260(1-2):16-22..32. X Zhang, Z Xu, YQ Xu, ZP Wang, ZK Wu, BY Tang, M Xiong, JP Yao, PW Sun, and FT Zhong. Surgical intervention for advanced valvular heart disease in 227 cases. Chin Med J (Engl) 2005; 118: 989-94.33. Czibik, G, Wu ZK, Berne GP, et al. Hypoxia-inducible factor 1 alpha is not activated by human heart preconditioning. J Mol Cell Cardiol 2004;36:723.34. Laurikka J, Wu ZK, Iisalo P, et al. Ischemic preconditioning improves myocardial performance in off-pump coronary artery bypass grafting. Chest 2002;121:1183-9. 35. Tarkka MR, Wu ZK. Ischaemic Preconditioning in CPB Surgery. Scand Cardiovase J . 2000;34: 231-232.在中文杂志发表的论文：1 刘子由,吴钟凯,陈光献,刘海. 大鼠心肌肥厚模型中血清白细胞介素-18及-10的变化. 中山大学学报·医学科学版 2009,30(3):280-2832 陈光献,唐白云,张金涛,吴钟凯. 心脏手术合并肺静脉高压术后近期分析. 中华全科医学 2009,7(5):447-4493 Guang-Xian Chen,Meng-Ya Liang,Hai Liu,Zhong-Kai Wu,et al. Tetralogy of Fallot with Absent Pulmonary Valve and Pulmonary Artery Aneurysm: A Case Report of Surgical Cure.South China Journal of Cardiology.2009,10(2):94-964 陈光献,张金涛,唐白云,吴钟凯. 先天性心脏病合并肺动脉高压术后近期分析. 中华全科医学 2009,7(8):791-7935 陈光献,唐白云,梁孟亚,刘海,吴钟凯. 远程预处理通过下调钙网蛋白高表达减轻在体大鼠心肌细胞缺血再灌注损伤. 病理生理杂志 2009,25(8):1469-14736 陈光献,梁孟亚,唐白云,张金涛,吴钟凯,张希. 肺动脉高压心脏手术后危象多因素分析. 中华全科医学 2009,7(9):909-9117 陈光献,唐白云,张希,熊迈,吴钟凯. 体外循环术后腹部并发症的防治. 中华胃肠外科杂志.2009,12(5):526-5278 Meng-Ya Liang, Guang-Xian Chen, Zhong-Kai Wu,et al.A procedure of combination of sequential internal thoracic artery grafting and cooley’s technique for complicated cse with multi-vessel disease,left ventricular anerysm and mitral reguragitation. South China Journal of Cardiology.2009,10(3):159-1639 Guang-Xian Chen,Hong-He Luo,Zhi-Ping Wang,et al.Pulmonary Artery Sarcoma：A Case Report of Surgical Cure and 1- Year Follow-up. South China Journal of Cardiology.2009,10(3):164-16710 陈光献,刘海,吴钟凯,郑红升. αB晶状体蛋白在不同预处理减轻在体大鼠心肌细胞缺血再灌注损伤的作用. 中华生物医学工程杂志 2009,15(5):325-32911 陈光献,龚凤球,罗红鹤,王治平,吴钟凯. 肺动脉肉瘤1例报告并文献复习. 误诊学杂志 2009,9(30):7316-731812 陈光献,张希,陈艳玲等.感染性心内膜炎近10年临床特点变迁.临床实用医学 2009,(10):1-313 陈光献,吴钟凯,唐白云,刘海,张希. 血清白介素8、10在心肌缺血预处理中的变化及其意义. 病理生理杂志 2009,25(11):2088-209214 陈光献,唐白云, 吴钟凯,梁孟亚,刘海. 钙网蛋白在不同预处理心肌细胞缺血再灌注的保护作用. 中华实验外科杂志 2009,26(11):1416-141915 陈光献,张希,陈艳玲,熊迈,吴钟凯. 感染性心内膜炎患者病原菌及其耐药率的分析. 热带医学杂志 2008,8(9):911-91416 陈光献,张希,熊迈,王治平,吴钟凯. 急诊冠脉搭桥初步经验. 实用医学杂志 2008,24(22):3896-389817 陈光献,吴钟凯,唐白云,刘海. 不同给药途径的腺苷预处理对大鼠缺血再灌注心肌的保护. 中华生物医学工程杂志 2008,14(6):413-41618 Nonlinear heart rate dynamics in off-pump coronary bypass grafting patients and the relevance with atrial fibrillation and ventricular tachycardia.South china journal of cardiology. 2007;8:76. 19 方丹青,姚尖平,张冬成,张希,王治平,徐颖琦,吴钟凯. 急诊冠状动脉搭桥术围术期手术效果分析. 热带医学杂志 2006,6(6):730-73220 低氧分压控制性再灌注与紫绀缺氧未成熟心肌保护。中华胸心血管外科杂志.2003年10月19（5）：297。（第三作者）。21 紫绀缺氧未成熟心肌对缺血-再灌注损伤耐受性的兔实验。中山医科大学学报；2003；24（6）：556-559。（第三作者）。22 低氧分压控制性再灌注与紫绀缺氧未成熟心肌保护。胸心血管外科杂志；2003；19（5）：297-300。（第五作者）。23 紫绀缺氧未成熟心肌对缺血-再灌注损伤耐受性的兔实验。中山医科大学学报；2003；24（6）：556-559。（第三作者）。24 胸骨正中小切口左心脏直视手术中的应用。胸心血管外科临床杂志 2002；9： 60-61。（第四作者）。25 电子束CT测定对冠心病患者心功能的评价。中山医科大学学报. 2002.9;23(5):351-353。 （第三作者）。26 联合灌注冷停搏液在瓣膜置换术中的心肌保护研究。中华实用外科杂志2002.19（增刊）:129-130。（第五作者）。27 高龄冠心病合并糖尿病手术治疗患者的临床分析。中华实用医药杂志。2002，2（2）：97。（第四作者）。28 体外循环术后肾损害原因及预后的回顾分析. 中山医科大学学报. 2001,22:305. （第三作者）。29 顺逆行结合灌注冷停跳液对心肌保护的作用. 中山医科大学学报. 2001,22:264. （第四作者）。30 婴幼儿心脏移植1例报告. 中山医科大学学报. 2001,22:261. （第六作者）。31 不停跳冠脉搭桥术及缺血预处理的保护效果。中山医科大学学报2001,22:276.（作者）。32 左挠动脉在冠脉搭桥术中的应用。中山医科大学学报2001, 22:274（作者）。33 浅谈拓宽心血管外科的课堂教学。中山医科大学学报（社科版）2001；4：151-168。（第三作者）。34 心内直视术后应激性高血糖胰岛素强化治疗。中华医学实践杂志 2005;16:38:40. （第四作者）。35 核转录因子-κB在体外循环术缺血预处理心肌保护机制中的作用中华实验外科杂志2007 Vol.24 No.2 P.207-208（第三作者）。36 急诊冠状动脉搭桥术围术期手术效果分析。热带医学杂志 2006； 6：730-732。37 1000例心脏瓣膜替换术的临床经验：中山医科大学学报1996,17：116-118。（第九作者）。38 布-加氏综合征。实用外科杂志；1990，9 ：489。（作者）39 软组织骨肉瘤——文献综述和个例报告。实用外科杂志；1989，4：211（作者）。专著 1 Wu ZK, Tarkka MR, Pehkonen E, et al. Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting. Year Book of Critical Care 2002:144-146. ISBN: 0-323-01518-2.2 Wu ZK. Ischemic Preconditioning in Coronary Artery Bypass Surgery. 2000. 主编. ISBN 981-44-4980-0.3 Wu ZK, Pehkonen E, Laurikka J, et al. Inflammatory Response in Stable and Unstable CABG Patients. Proceedings of Cardiovascular Surgery.2000, 263-268. ISBN 981-44-4980-0.4 Wu ZK, Tarkka MR, Eloranta J, et al. Effect of Preconditioning on Free Radicals Generation in CABG Patients。Proceedings of Cardiovascular Surgery. 2000. C.2000,33-38. ISBN 981-44-4980-0.5 吴钟凯：外科症状鉴别诊断学，第十二章: 吞咽困难，292-329, 福建科学技术出版社，2005年1月，主编：梁力建， ISBN7-5335-2460-8。6 重症二尖瓣病变MVRP与MVR近期对比。1995，心脏瓣膜外科专题研讨会论文集266-273。（第五作者）。7 吴钟凯：急性冠脉综合症外科治疗。急性冠脉综合症广东科技出版社，主编：ISBN：9787535943897。8 吴钟凯：副主编。先天性心脏病外科治疗关键技术。科学技术文献出版社。主编：王治平。2010ISBN：9787502367244。国际学术会议大会报告:1. Ischaemic preconditioning has beneficial effects on left ventricular haemodynamic function after CABG Operation. The 48th Annual Meeting of SATS and SCANSECT. Aarb?rg, Denmark, 1999, oral presentation. 2. Protective effect of unstable angina in coronary artery bypass surgery. The 49th Annual Meeting of SATS And SCANSECT, 2000, Sweden, poster.3. Effect of ischemic preconditioning (IP) on myocardial protection in CABG patients: Can the free radicals act as a trigger for IP? 14th Annual Meeting of the European Association for Cardio-Thoracic Surgery, 2000, Frankfurt, Germany, oral presentation.4. Effect of ischaemic preconditioning, cardiopulmonary bypass and myocardial ischaemic/reperfusion on free radicals generation in CABG patients. 49th International Congress of the European Society for Cardiovascular Surgery. 2000, Dresden, Germany, oral presentation.5. Preceding unstable angina affects inflammatory response and haemodynamics after coronary artery bypass surgery. 49th International Congress of the European Society for Cardiovascular Surgery. 2000, Dresden, Germany, poster.6. Ischaemic preconditioning reduces the incidence of atrial fibrillation in CABG patients. 51st International Congress of the European Society for Cardiovascular Surgery. June-July 2002, Helsinki, Finland, oral presentation. 7. Cardiomyocyte apoptosis and ischemic preconditioning in open heart surgery. The 52th Annual Meeting of SATS And SCANSECT. Turku, finland, 2003, oral presentation.8. Cardiac autonomic regulation is involved in the IP protective mechanism in CABG patients. The 52th Annual Meeting of SATS And SCANSECT. Turku, finland, 2003, oral poster.9. Cardiac autonomic regulation in CABG patients and the preconditioning effects. The 14th World Congress of The World Society of Cardiaothoracic Surgery (215), Bei, China.10. Mitral valve replacement with preservation of subvalvular structure. 届中芬心脏外科广州研讨会，广州2007。大会主席，主持，主讲。11. Gradual oxygen controlled reperfusion attenuated myocardial ischemia-reperfusion injury in the early stage following cardiopulmonary bypass.The 56th Annual Meeting of SATS And SCANSECT. Tampere, Finland, 2011, oral presentation.
