阎作勤,男,主任医师,教授,副院长,博士生导师,中华创伤学会委员,上海创伤分会主任委员,中华骨科学分会关节学组委员. 具有丰富的临床经验,尤其擅长微创人工关节置换技术以及先天性畸形、髋关节发育不好、股骨头坏死的诊治,并开展了一些新的技术:1、2003年上海市较早开展了骨髓基质干细胞治疗股骨头坏死的临床研究;2、在国内较早引进T-SAW,进行椎板大块切除回植治疗椎管内肿瘤,获得了良好的,在此基础上,改进Tomita大块切除椎体肿瘤技术,针对手术过程中存在的问题,设计了专门器械(已申请专利),简化作难度,降低手术危险,提高了手术的靠谱性,大大提高了脊柱肿瘤的治疗水平(包括原发性和转移性),降低了并发症的发生。 申请人作为项目负责人承担上海市课题和上海市自然科学基金二项,作为第三参与者参加自然科学基金、973子课题项目的科研工作。参加编写或编译的专著有:《实用外科学》、《脊柱创伤外科学》、《实用骨科手册》、《周围神经损伤基础与临床研究》、《外科手术并发症的预防与处理》、《O’connor关节镜外科学》等。2006年主译出版了66万字的《脊柱外科手术图谱》专著一本。获得3项发明专利授权,申请一项专利。在骨科领域核心期刊发表论文40余篇,近5年发表18篇,其中SCI论文6篇,核心期刊11篇。在股骨头坏死研究方面发表SCI论文两篇(IF2.9,2.7),在国际上首先发现采用利福平增强P-gp的活性有助于降低激素性坏死的发生,论文发表在国际的期刊Calsif Tissue International,为降低激素性股骨头坏死的发生提出了一种新的思路。 1. Predictive value of single photon emission computerized tomography and computerized tomography in osteonecrosis after femoral neck fracture: a prospective study. Yuan HF, Shen F, Zhang J, Shi HC, Gu YS, Yan ZQ. Int Orthop. 2015 Feb 25. [Epub ahead of print] PMID:25711398 2. Protective effects of total saponins of panax notoginseng on steroid-induced avascular necrosis of the femoral head in vivo and in vitro. Yuan HF, Pan JF, Li S, Guo CA, Liu SH, Yan ZQ. Evid Based Complement Alternat Med. 2015;2015:165679. doi: 10.1155/2015/165679. Epub 2015 Jan 28. PMID: 25694788 3. Analysis of altered microRNA expression profile in the reparative interface of the femoral head with osteonecrosis. Yuan HF, Von Roemeling C, Gao HD, Zhang J, Guo CA, Yan ZQ. Exp Mol Pathol. 2015 Apr;98(2):158-63. doi: 10.1016/j.yexmp.2015.01.002. 4. Mediopatellar plica as a risk factor for knee osteoarthritis? Yuan HF, Guo CA, Yan ZQ. Chin Med J (Engl). 2015 Jan 20;128(2):277-8. doi: 10.4103/0366-6999.149237. No abstract available. PMID:25591575 5. A "two-incision" approach for en bloc resection of periacetabular tumors with illustrations from a cadaver. Guo CA, Yan ZQ. Orthop Surg. 2014 Feb;6(1):60-4. doi: 10.1111/os.12094. 6.Modified total En-bloc spondylectomy in thoracic vertebra tumour European Spine Journal 2010 DOI: 10.1007/s00586-010-1618-0 7.Effects of P-Glycoprotein on Steroid-Induced Osteonecrosis of the Femoral Head Calcif Tissue Int (2010) 87:246–253 8.Effect of rifampicin on the risk of steroid-induced osteonecrosis of th femoral head. Orthopaedic Surgery 2010,2(2):124-133 9.Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defects. J Orthop Res 2010,28:1064–1070, 10.Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. J Orthop Res 2009, 27(4):442-446. 11.Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion.Chinese J. of Traumatology 2006,2(1):3-7.